Learning to write successful grant applications takes significant time and effort. This paper presents knowledge, expertise, and strategies from experienced grant applicants and grant officers across several disciplines to support early career scholars and first-time grant writers, with particular guidance for interdisciplinary collaboration. Many Agricultural and Applied Economists are invited to participate in interdisciplinary grant applications. It is important to fully understand the types of projects, nature of collaboration, co-investigators’ characteristics, expected contributions, anticipated benefits, and valuation of collaborative research by one’s peers before initiating new opportunities. Leading and participating in interdisciplinary teams also requires mentorship, patience, professionalism, and excellent communication beyond the scientific merits. This paper shares practical insights to guide scholars through the grant-writing processes beginning with nurturing a mindset, preparing for a consistent work ethic, actively seeking advice, identifying targeted programs, matching a programs’ priorities, a step-by-step framework for team creation and management, effectively managing time and pressure, and transforming failure into success.